The Chicago Biomedical Consortium (CBC) is driving innovation in life sciences by funding high-potential projects across diverse therapeutic areas and stages of development. Through its seed funding programs, CBC provides critical early-stage support to researchers working on cutting-edge discoveries in a wide range of fields such as oncology, neuroscience, rare diseases, and inflammation and immunology.
A key differentiator of CBC’s approach is its industry-grade diligence process, which ensures that funded projects are not only scientifically innovative but also positioned for long-term success. By incorporating rigorous evaluation criteria that align with industry standards, the CBC helps researchers refine their development strategies, strengthen their commercialization potential, and attract further investment from pharmaceutical companies and venture capital firms.
| Therapy Area | Modality | Target/MOA | Indication | Target Val | Hit ID | Lead ID | Lead Op | DC Nom | Investigator |
| Oncology | Small Mol | Mut-KRAS pathway | KRAS-mutant tumors | Kelley | |||||
| Biologic | IL13RA2,EGFRvIII | GBM | Balyasnikova | Small Mol | MYC | Solid tumors | Abdulkadir | ||
| PROTAC | Dot1L | ALL | Abdulkadir | ||||||
| Small Mol | PLEK2 | MDS | Ji | ||||||
| Small Mol | UBE3A | HPV+HNSCC | Kiyokawa | ||||||
| Cell Tx | CAR-T Platform | Liquid tunors | Shukla | Small molecule | TDO2 | Uterine Fibroids | Bulan | Data Platform | Target ID | Solid tumors | Raman |
| Inflammation & Immunology | Nanoparticle | mTOR | T1D and autoimmune | Scott | |||||
| Peptide | KLC1c | Cardiac IRI | Muller | Small Mol | Synthetic melanin | Radiation dermatitis | Gianneschi | ||
| Platform | NFkB/IRF | Vaccine reactogencity | Esser-Kahn | ||||||
| Small Mol | CLDN2 | IBD | Weber | ||||||
| Rare disease | Gene Tx | COL7A1 | RDEB | Wu | |||||
| Small molecule/td> | TNNI3 | Hypertrophic CM | Goldspink | ||||||
| Neuroscience | Small molecule | KALRN | Fragile X Syndrome | Penzes | |||||
| Platform | Target ID | Rett Syndrome | Kozorovitsky |
Current Portfolio Projects
